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Current evidence is not sufficient to support clinical use beyond research or investigational settings

Progress typically builds over several months, and as with any medical weight-loss plan, the results can vary from patient to patient and depend on consistency, lifestyle changes, and dosage

Despite the development of new medications and therapeutic approaches, such as phosphodiesterase inhibitors and sphingosine receptor modulators, only approximately 40% of patients achieve clinical remission after one year, highlighting the need for new treatment modalities [320,321,322]

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